Even though the events of Resident Evil 5 make this obvious, Wesker has proven himself to have superhuman capabilities, and Umbrella’s other projects Tyrant T-103 (Resident Evil 2) and Nemesis have proven themselves capable of surviving immersion in molten metal, and in Nemesis’ case, being dumped into highly-concentrated acid and still hang onto life after a direct hit with a massive railcannon. However, he wont be in Resident Evil 6.
Wesker’s voice actor D.C. Douglas tweeted that he did not work on Resident Evil 6. He also confirmed this on his Facebook, stating once again that he did not do any voiceovers for the game. He has said that it looks awesome, and that he has other things coming, possibly as a voice actor.
There are theories that even though Albert Wesker wont be appearing following being sent straight into lava during the events of Resident Evil 5, the twelfth of the thirteen Project W candidates, Alex Wesker, may be in the game.
If you skipped out on Resident Evil 5 due to it getting rather lackluster reception, I recommend reading these wikia articles so you can brush up on the lore and canon that you would have missed or otherwise forgotten about.
http://residentevil.wikia.com/Albert_Wesker
http://residentevil.wikia.com/Alex_Wesker
http://residentevil.wikia.com/Project_W
Being that Alex Wesker’s status has not been confirmed to be alive or dead, and that someone with superhuman capabilities has been seen, it’s very likely that this result of the eugenics project will be the next primary antagonist. He will be missed in the series but Wesker was a fantastic villain and served his role well.
Brad Heilman
wesker needs to come back if not in this one another they build so much around him and any realy go vallian never dies till he takes out alot of people and acouple heros two so bring him back scared and brunt he has to behind re 6 outbreak hes the only one who has alot of bow and samples and the mind set to unleash all it on everone
Rian Quenlin
A good villain dies once he’s served his purpose in the story, actually. Ones that don’t die quickly become very annoying.
cowl phoenix
f you played re5 to the end wesker used Uroboros to fight chris and sheva you know his arm thingy. he also had blond hair and red eye’s. if you have the demo of re6 or you watch video’s you will note that in jake’s campaign ustanak the big monster chasing jake is big has red eyes, little chunks of blond hair and a big metal arm. So i think wesker is like nemesis and they couldnt save his arm so i dont kow for sure but ill put my money on it and just say that is wesker